| | Bill,
================ Also, early man ate meat that was far leaner than today's fat laden fair. So, unless you get meat that lean, which you can't unless you eat only wild game, you will not be able to follow the "evolutionary diet"; if you try, you'll simply be eating a lot more saturated fat than you should and will be putting yourself at risk of heart disease and cancer. ================
Good point, Bill. One of the healthy changes I've made since talking to you (wondering if YOU'VE made any healthy changes -- since being exposed to my rationally-compelling evidence) -- is to consume more foul, and less beef.
Of course, getting fish oil in the diet, cancels out most of the drawbacks of red meat. But there's that damn 'sialic acid' I mentioned before -- it seems to carry a unique risk; and it seems to coincide with the intake of grain-fed red meat.
As I said before, you can eat chicken until it is coming out of your ears -- and there's no data on earth to show that your health will suffer even a tad for that. But there does appear to be a risk with the consumption of red meat, it's small, but statistically-significant.
Also, with regard to heart disease and cancer (from saturated fat intake) ...
The concern about heart disease has been adequately diminished -- which makes me question your epistemological sincerity, as you continue to ignore the fact that high-saturated fat diets (like the Atkins diet) -- reduce the risk for heart disease.
It's as if you'd rather believe that your decades-old belief has been true all along -- than for it to actually correspond to the facts of reality. This is a little disconcerting, and especially so from the likes of yourself (someone with such background epistemological virtue).
The cancer issue is another story, and it appears that fish oil is the saving grace, again ...
================================= Cancer Res. 2004 Sep 15;64(18):6797-804.
Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat.
* Davidson LA, * Nguyen DV, * Hokanson RM, * Callaway ES, * Isett RB, * Turner ND, * Dougherty ER, * Wang N, * Lupton JR, * Carroll RJ, * Chapkin RS.
Faculty of Nutrition, Texas A&M University, College Station, Texas 77843-2471, USA.
... Only the consumption of n-3 PUFA exerted a protective effect at the initiation (DNA adduct formation) and promotional (aberrant crypt foci) stages. Importantly, microarray analysis of colonocyte gene expression profiles discerned fundamental differences among animals treated with n-3 PUFA at both the 12 hours and 10-week time points.
Thus, in addition to demonstrating that dietary fat composition alters the molecular portrait of gene expression profiles in the colonic epithelium at both the initiation and promotional stages of tumor development, these findings indicate that the chemopreventive effect of fish oil is due to the direct action of n-3 PUFA and not to a reduction in the content of n-6 PUFA. =================================
Recap: Animal evidence suggests that, as far as the risk of colon cancer goes, the risk-producing omega-6 fats from beef can be effectively countered by a proportionate intake of omega-3 fats from fish -- leaving liberal beef-eaters with no net increase in colon cancer risk.
Also to that end, butyrate (found in high amounts in butter) has shown protective against colon cancer ...
================================= J Clin Gastroenterol. 2006 Mar;40(3):235-43.
Colonic health: fermentation and short chain fatty acids.
* Wong JM, * de Souza R, * Kendall CW, * Emam A, * Jenkins DJ.
Clinical Nutrition and Risk Factor Modification Center, St Michael's Hospital, Toronto, Ont, Canada. julia.wong@utoronto.ca
Butyrate has been studied for its role in nourishing the colonic mucosa and in the prevention of cancer of the colon, by promoting cell differentiation, cell-cycle arrest and apoptosis of transformed colonocytes; inhibiting the enzyme histone deacetylase and decreasing the transformation of primary to secondary bile acids as a result of colonic acidification.
Therefore, a greater increase in SCFA production and potentially a greater delivery of SCFA, specifically butyrate, to the distal colon may result in a protective effect. Butyrate irrigation (enema) has also been suggested in the treatment of colitis.
More human studies are now needed, especially, given the diverse nature of carbohydrate substrates and the SCFA patterns resulting from their fermentation. Short-term and long-term human studies are particularly required on SCFAs in relation to markers of cancer risk. These studies will be key to the success of dietary recommendations to maximize colonic disease prevention. =================================
... and fatty acids from beef are possibly colono-protective ...
================================= Br J Nutr. 2006 Feb;95(2):346-52.
Beef conjugated linoleic acid isomers reduce human cancer cell growth even when associated with other beef fatty acids.
* De La Torre A, * Debiton E, * Juaneda P, * Durand D, * Chardigny JM, * Barthomeuf C, * Bauchart D, * Gruffat D.
INRA, Unite de Recherche sur les Herbivores, Equipe Nutriments et Metabolismes, 63122 Saint Genes-Champanelle, France.
Compared with cells incubated without FA, the number of cancer cells was reduced from 25 to 67 % (P<0.0001) following FA treatment. Antiproliferative effects of CLA mixtures varied in magnitude according to the source of FA, the CLA composition and the cell lines.
CLA mixtures naturally present in beef inhibited the proliferation of human cancer cell lines, a high content in cis-trans isomers allowing the most important antiproliferative effect. Beef total FA exhibited a greater growth-inhibitory activity than their corresponding CLA-enriched fractions.
These results suggested that either beef FA other than beef CLA could possess antiproliferative properties and/or the existence of complementary effects of non-conjugated FA and CLA, which could favour the antiproliferative properties of beef total FA.
PMID: 16469152 [PubMed - indexed for MEDLINE] =================================
So, as far as heart disease and colon cancer go -- there's seems to be no beef with beef (even though much, if not most, PhD's -- and other otherwise smart folks -- have had this notion in their heads for decades).
;-)
Ed
(Edited by Ed Thompson on 8/26, 10:40pm)
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